-Opioid receptor-mediated enhancement of the hyperpolarization-activated current (Ih) through mobilization of intracellular calcium in rat nucleus raphe magnus
نویسندگان
چکیده
منابع مشابه
Dopamine modulates inwardly rectifying hyperpolarization-activated current (Ih) in cultured rat olfactory receptor neurons.
The presence of dopamine receptors in olfactory receptor neurons (ORNs) suggests that odor sensitivity may be modulated by neurotransmitters at the level of primary sensory neurons. Using standard patch-clamp techniques on rat ORNs, we found that 1 microM dopamine, 500 microM SQ 22536 (SQ, an adenylyl cyclase inhibitor), 20 and 50 microM quinpirole (a selective dopamine D2 receptor agonist), an...
متن کاملExpression of a functional hyperpolarization-activated current (Ih) in the mouse nucleus reticularis thalami.
The GABAergic neurons of the nucleus reticularis thalami (nRT) express the type 2 hyperpolarization-activated cAMP-sensitive (HCN2) subunit mRNA, but surprisingly, they were reported to lack the hyperpolarization-activated (Ih) current carried by this subunit. Using the voltage-clamp recordings in the thalamocortical slice preparation of the newborn and juvenile mice (P6-P23), we demonstrate th...
متن کاملAction of serotonin on the hyperpolarization-activated cation current (Ih) in rat CA1 hippocampal neurons.
We studied the effects of serotonin (5-HT) on hippocampal CA1 pyramidal neurons. In current-clamp mode, 5-HT induced a hyperpolarization and reduction of excitability due to the opening of inward rectifier K+ channels, followed by a late depolarization and partial restoration of excitability. These two components could be dissociated, as in the presence of BaCl2 to block K+ channels, 5-HT induc...
متن کاملOxytocin in rat nucleus raphe magnus influences pain modulation
The main function of Nucleus raphe magnus (NRM) is mostly pain mediation. Our previous study has demonstrated that oxytocin (OXT) regulates antinociception through the central nervous system rather than the peripheral organs, and pain stimulation increases OXT concentration in the NRM. The experiment was designed to investigate OXT in the rat NRM effect on pain modulation. The results showed th...
متن کاملTolerance to Non-Opioid Analgesics is Opioid Sensitive in the Nucleus Raphe Magnus
Repeated injection of opioid analgesics can lead to a progressive loss of effect. This phenomenon is known as tolerance. Several lines of investigations have shown that systemic, intraperitoneal administration or the microinjection of non-opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) into the midbrain periaqueductal gray matter induces antinociception with some effects of to...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2003
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2002.037622